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Research Library

The evidence, curated.

Landmark trials, guideline summaries, and evidence updates — organised so clinicians can find what matters, and patients can see what shapes recommendations.

landmark trial

ASPRE: Aspirin for Prevention of Preterm Preeclampsia

New England Journal of Medicine · 2017 · doi:10.1056/NEJMoa1704559

A landmark RCT demonstrating a ~60% reduction in preterm preeclampsia with aspirin 150 mg nightly, started before 16 weeks in screened high-risk women.

  • Start before 16 weeks
  • 150 mg dose
  • Screen using combined first-trimester algorithm
evidence summary

ESHRE Guideline on Recurrent Pregnancy Loss — Update

Human Reproduction Open · 2023 · doi:10.1093/hropen/hoad002

Updated evidence synthesis reshaping investigation thresholds and management pathways for RPL.

  • Two-loss threshold
  • Selective thrombophilia screen
  • APS treatment with aspirin + LMWH